Article

Removal of the C6 vaccinia virus interferon-β inhibitor in the hepatitis C vaccine candidate MVA-HCV elicited in mice high immunogenicity in spite of reduced host gene expression

2018-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Hepatitis C virus (HCV) represents a major global health problem for which a vaccine is not available. MVA-HCV is a unique HCV vaccine candidate based in the modified vaccinia virus Ankara (MVA) vector expressing the nearly full-length genome of HCV genotype 1a that elicits broad and polyfunctional CD8 + T-cell responses in mice. With the aim to improve the immune response of MVA-HCV and due to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e21b1e1-2700-510a-844e-f8178fbee510
DOI: 10.1101/330902

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Removal of the C6 vaccinia virus interferon-β inhibitor in the hepatitis C vaccine candidate MVA-HCV elicited in mice high immunogenicity in spite of reduced host gene expressionDOI 10.1101/330902Read

Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling PathwaysSemantic proximity Read

A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.Semantic proximity Read

Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 AntigensSemantic proximity Read

Status of hepatitis C virus vaccination: Recent update.Semantic proximity Read

Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-C.Semantic proximity Read

Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonistSemantic proximity Read

Prospects for prophylactic and therapeutic vaccines against hepatitis C virus.Semantic proximity Read

Alphavirus-based Vaccines Encoding Nonstructural Proteins of Hepatitis C Virus Induce Robust and Protective T-cell ResponsesSemantic proximity Read

Progress in the development of vaccines for hepatitis C virus infection.Semantic proximity Read

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.Semantic proximity Read

Suppression of Host Immune Response by the Core Protein of Hepatitis C Virus: Possible Implications for Hepatitis C Virus PersistenceSemantic proximity Read

A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice.Semantic proximity Read