Article

Niclosamide Targets Inflammatory and Profibrotic Pathways in Amyotrophic Lateral Sclerosis

2021-01-05

Abstract excerpt

<title>Abstract</title> <p>BackgroundAn increasing number of studies evidence that amyotrophic lateral sclerosis (ALS) is characterized by extensive alterations in different cell types and in different regions besides the CNS. We previously reported the up-regulation in ALS models of a gene called fibroblast-specific protein (FSP)-1 or S100A4, generally recognized as a pro-inflammatory and profibrotic factor. Sin...

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Literature Corpus work: cdc3c6ff-2fea-5505-9148-0b1f00535042
DOI: 10.21203/rs.3.rs-138253/v1

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