Article

Frataxin deficiency in proprioceptive neurons is causal to inflammatory and glial responses in dorsal root ganglia

2024-04-19

Abstract excerpt

Friedreich ataxia (FA), the most common recessive hereditary ataxia, is an early-onset neurodegenerative disease characterized by pathological changes occurring first in the peripheral dorsal root ganglia (DRG), with loss of the large sensory proprioceptive neurons, leading to ganglionopathy and proprioceptive deficits. FA is caused by a mutation in frataxin gene ( Fxn ), leading to reduced expression of frataxin...

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Literature Corpus work: bae8e61d-ed10-57bf-8daa-4c4a3d21dc1a
DOI: 10.1101/2024.04.16.589410

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