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Article

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.

Molecular neurobiology - 1 May 2018

Cunha Carolina, Santos Catarina, Gomes Cátia, Fernandes Adelaide, Correia Alexandra Marçal, Sebastião Ana Maria, Vaz Ana Rita, Brites Dora

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause. Absence of specific targets and biomarkers compromise the development of new therapeutic strategies and of innovative tools to stratify patients and assess their responses to treatment. Here, we investigate changes in neuroprotective-neuroinflammatory actions in the spinal cord of SOD1 G93A mice, at presymptomatic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28612258
DOI: 10.1007/s12035-017-0631-2

Genes

GFAP
SOD1
CCL21
HMGB1
NLRP3

Variants

Provenance

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