Article

Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

2023-01-20

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of upper and lower motor neurons. ALS is on a pathogenetic disease spectrum with frontotemporal dementia (FTD), with patients sometimes experiencing elements of both conditions (ALS-FTSD). For mutations associated with ALS-FTSD, such as the C9orf72 hexanucleotide repeat expansion (HRE), the factors influencing whe...

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Literature Corpus work: db8af6c6-f7cb-54da-baad-f34651b2df6e
DOI: 10.1101/2023.01.19.524561

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