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Article

Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis.

Journal of neuroinflammation - 12 Jun 2021

Milani Martina, Mammarella Eleonora, Rossi Simona, Miele Chiara, Lattante Serena, Sabatelli Mario, Cozzolino Mauro, D'Ambrosi Nadia, Apolloni Savina

Abstract excerpt

BACKGROUND: An increasing number of studies evidences that amyotrophic lateral sclerosis (ALS) is characterized by extensive alterations in different cell types and in different regions besides the CNS. We previously reported the upregulation in ALS models of a gene called fibroblast-specific protein-1 or S100A4, recognized as a pro-inflammatory and profibrotic factor. Since inflammation and fibrosis are often...

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Identifiers

PMID: 34118929
DOI: 10.1186/s12974-021-02184-1
PMCID: PMC8196441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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