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Article

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2016

Potenza Rosa Luisa, De Simone Roberta, Armida Monica, Mazziotti Valentina, Pèzzola Antonella, Popoli Patrizia, Minghetti Luisa

Abstract excerpt

Fingolimod phosphate (FTY720), the first approved oral therapy for multiple sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central nervous system, however, indicate a potentially broader spectrum of activity in neurodegenerative diseases. In the present study, we investigated the possible effects of fingolimod in a mouse model of amyotrophic lateral sclerosis (ALS), a...

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Identifiers

PMID: 27456702
DOI: 10.1007/s13311-016-0462-2
PMCID: PMC5081121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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