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Is Innate Immunity and Inflammasomes Involved in Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)?

Recent patents on endocrine, metabolic & immune drug discovery - 1 Jan 2015

Volpe Caroline M O, Nogueira-Machado Jose A

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is an axonopathy with adultonset, progressive and irreversible degeneration of upper and lower motor neurons. Around 90% of ALS is considered as sporadic ALS (sALS) without apparent genetic cause while in the familial type of ALS (fALS) at least one affected blood relative needs to be identified. Both sALS and fALS show similar progression and...

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Identifiers

PMID: 25845840
DOI: 10.2174/1872214809666150407111420

Genes

NRL
SOD1

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