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Article

The Links between ALS and NF-κB.

International journal of molecular sciences - 8 Apr 2021

Källstig Emma, McCabe Brian D, Schneider Bernard L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease wherein motor neuron degeneration leads to muscle weakness, progressive paralysis, and death within 3-5 years of diagnosis. Currently, the cause of ALS is unknown but, as with several neurodegenerative diseases, the potential role of neuroinflammation has become an increasingly popular hypothesis in ALS research. Indeed, upregulation of...

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PMID: 33918092
DOI: 10.3390/ijms22083875
PMCID: PMC8070122

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