Article

VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules

2022-06-03

Abstract excerpt

<h4>ABSTRACT</h4> The detyrosination/tyrosination cycle of α-tubulin is critical for proper cell functioning. VASH1-SVBP and VASH2-SVBP are ubiquitous enzyme complexes involved in microtubule detyrosination. However, little is known about their mode of action. Here, we show in reconstituted systems and in cells that VASH1-SVBP and VASH2-SVBP drive global and local detyrosination of microtubules, respectively. We...

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Literature Corpus work: cd9c3754-2176-59f0-930d-cf5b96c43202
DOI: 10.1101/2022.06.02.494516

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