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Article

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

1 Dec 2019

Abstract excerpt

The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we demonstrate that SVBP acts as a bona fide activator of both enzymes. Phylogenetic analysis of the vasohibin family revealed that...

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PMID: 31851940
DOI: 10.1016/j.celrep.2019.11.074

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