Article

Myofibrillar malformations that arise in mdx muscle fibers are driven by detyrosinated microtubules

2023-03-29

Abstract excerpt

In Duchenne muscular dystrophy (DMD), alterations in the myofibrillar structure of skeletal muscle fibers that impair contractile function and increase injury susceptibility arise as a consequence of dystrophic pathology. In murine DMD ( mdx ), myofibrillar alterations are abundant in advanced pathology (>4 months), an age where we formerly established the densification of microtubules (MTs) post-translationally...

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Literature Corpus work: 92f89e3a-d76e-5575-942b-5e9ea2a79480
DOI: 10.1101/2023.03.27.534405

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