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Article

Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers

25 Aug 2023

Abstract excerpt

Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal muscle contractile function and increases susceptibility to contraction injury. In murine Duchenne muscular dystrophy (mdx), myofibrillar alterations are abundant in advanced pathology (>4 months), an age where we formerly established densified microtubule (MT) arrays enriched in detyrosinated (deTyr) tubulin as negative...

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Identifiers

PMID: 37691825
DOI: 10.3389/fcell.2023.1209542

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Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibersPMID 37691825Read ↗

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