Article

Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formation

2025-11-30

Abstract excerpt

Microtubule severing enzyme spastin plays pivotal roles in cytokinesis and neuronal outgrowth, and its mutations cause hereditary spastic paraplegia (HSP). Here we show that, at physiological tubulin concentrations, human spastin behaves predominantly as an ATPase- independent microtubule nucleator rather than a severase. Biochemical and structural analyses revealed that spastin assembles tubulin into stacked-ring...

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Identifiers and source

Literature Corpus work: 3fb26261-1017-547d-9475-4f1451f0f465
DOI: 10.1101/2025.11.28.691112

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