Article

Suppressing microtubule detyrosination augments AAV2 endosomal escape and gene delivery

2025-08-13

Abstract excerpt

Adeno-associated virus (AAV) is a widely used vector for gene delivery, yet the host intracellular trafficking barriers often limit its efficacy. Here, we identify microtubule detyrosination—a tubulin post-translational modification—as a key regulator of AAV2 endo-lysosomal processing. Using super-resolution microscopy (SIM/STORM), we show that upon AAV2 endocytosis, the host upregulates microtubule detyrosination...

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Identifiers and source

Literature Corpus work: 3118b21d-c986-5f36-b1c8-9c7710a41116
DOI: 10.1101/2025.08.12.669862

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