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Article

Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics.

American journal of human genetics - 2 Dec 2021

He Zihuai, Le Guen Yann, Liu Linxi, Lee Justin, Ma Shiyang, Yang Andrew C, Liu Xiaoxia, Rutledge Jarod, Losada Patricia Moran, Song Bowen, Belloy Michael E, Butler Robert R, Longo Frank M, Tang Hua, Mormino Elizabeth C, Wyss-Coray Tony, Greicius Michael D, Ionita-Laza Iuliana

Abstract excerpt

Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal variants in a genome-wide analysis. However, because of the substantial computational cost for generating knockoffs, existing knockoff approaches cannot analyze millions of rare genetic variants in biobank-scale whole-genome sequencing and whole-genome imputed...

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PMID: 34767756
DOI: 10.1016/j.ajhg.2021.10.009
PMCID: PMC8715147

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EGFR

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