Article

Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting

2025-11-19

Abstract excerpt

<title>Abstract</title> <p> Rare and short-lived DNA conformations are proposed to be key drivers of mutagenesis, yet assessing their contribution to mutational signatures found in human cancers remains challenging. Here, we developed an approach that quantifies the sequence-dependent propensity to form a rare DNA conformation and compares the resulting fingerprint against cancer mutational signatures. Using <s...

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Literature Corpus work: cd6aad6a-52e8-5784-88f8-a72ba8372d01
DOI: 10.21203/rs.3.rs-8012102/v1

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