Article
Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting.
Nature communications - 23 Apr 2026
Szekely Or, Lee Yeongjoon, Rangadurai Atul K, Guseva Serafima, Cooksey Joshua, Faison Edgar M, Zalenski Nikita, Zhang Qi, Suo Zucai, Al-Hashimi Hashim M
Abstract excerpt
Rare and short-lived DNA conformations are proposed to be key drivers of mutagenesis, yet assessing their contribution to mutational signatures found in human cancers remains challenging. Here, we develop an approach that quantifies the sequence-dependent propensity to form a rare DNA conformation and compare the resulting fingerprint against cancer mutational signatures. Using 19F NMR, we measure the propensity...
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