Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic.

Abstract excerpt

DNA repair of mutagenic lesions is imperfect, allowing mutations to accumulate unevenly across the genome. In base excision repair, glycosylases must locate rare damaged bases embedded in diverse sequence contexts, yet how these contexts shape recognition and mutational outcomes remains unresolved. Here, we introduce a high-throughput approach that quantifies glycosylase binding across thousands of...

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