Article

Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I Lissencephaly

2020-08-21

Abstract excerpt

<h4>ABSTRACT</h4> Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency of the LIS1 gene and is characterized in humans by agyria, mislamination of brain structures, developmental delays, and epilepsy. Here, we investigate the impact of LIS1 mutation on the cellular migration, morphophysiology, microcircuitry and genomics of mouse hippocampal CA1 parvalbumin-containing inhibitory inte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46abe64a-9c6b-55d9-9b2c-cca1cab892af
DOI: 10.1101/2020.08.21.262014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I LissencephalyDOI 10.1101/2020.08.21.262014Read

Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice.Semantic proximity Read

Dlx2 reprograms the transcriptome and laminar position of glia-derived Ascl1-induced interneuronsSemantic proximity Read

Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defectsSemantic proximity Read

Aberrant sorting of hippocampal complex pyramidal cells in Type I Lissencephaly alters topological innervationSemantic proximity Read

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra SyndromeSemantic proximity Read

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortexSemantic proximity Read

Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in <i>SCN8A</i> Epileptic EncephalopathySemantic proximity Read

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet SyndromeSemantic proximity Read

Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient InterneuronsSemantic proximity Read

Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet SyndromeSemantic proximity Read

Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathySemantic proximity Read

Deficiency of intellectual disability-related gene <i>Brpf1</i> reduced inhibitory neurotransmission and <i>Map2k7</i> expression in GABAergic interneuronsSemantic proximity Read