Article

Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

2024-05-30

Abstract excerpt

<h4>SUMMARY</h4> Oligodendrocyte lineage cells (OLCs) are lost in many CNS diseases. Here, we investigate the generation of new OLCs via ectopic expression of Sox10, Olig2 or Nkx6 . 2 in mouse postnatal astrocytes. Using stringent analyses including, Aldh1l1-astrocyte fate mapping and live cell imaging we confirm that Sox10 and Olig2 , but not Nkx6 . 2 , convert Aldh1l1 pos astrocytes to induced OLCs (iOL...

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Literature Corpus work: 2e2de6cb-bc08-527d-8ef0-f0759741b06a
DOI: 10.1101/2024.05.28.596294

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