Article

Polygenic Risk Score Effectively Predicts Risk of Depression Onset in Alzheimer’s Disease

2021-08-27

Abstract excerpt

<title>Abstract</title> <p>Introduction: Depression is a common, though heterogenous, comorbidity in late-onset Alzheimer’s Disease (LOAD) patients. In addition, individuals with depression are at greater risk to develop LOAD. In previous work, we demonstrated shared genetic etiology between depression and LOAD. Collectively, this evidence suggested interactions between depression and LOAD. However, the underpinn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd2a3d2c-c639-57be-81f9-061d8be35c73
DOI: 10.21203/rs.3.rs-845772/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic Risk Score Effectively Predicts Risk of Depression Onset in Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-845772/v1Read

Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk VariantsSemantic proximity Read

Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.Semantic proximity Read

Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.Semantic proximity Read

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data.Semantic proximity Read

Age of onset and family history as indicators of polygenic risk for major depression.Semantic proximity Read

Alzheimer's disease genetic burden is associated with mid-life depression among persons with normal cognition.Semantic proximity Read

Epistatic Features and Machine Learning Improve Alzheimer’s Risk Prediction Over Polygenic Risk ScoresSemantic proximity Read

Predicting Alzheimer’s Trajectory: A Multi-PRS Machine Learning Approach for Early Diagnosis and Progression ForecastingSemantic proximity Read

Genetic evidence for a causal role of depression in late-onset Alzheimer disease: A Mendelian randomization study.Semantic proximity Read

Genetic overlap between major depression, bipolar disorder and Alzheimer’s DiseaseSemantic proximity Read

Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy casesSemantic proximity Read

A family study of Alzheimer disease and early- and late-onset depression in elderly patients.Semantic proximity Read