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Article

Alzheimer's disease genetic burden is associated with mid-life depression among persons with normal cognition.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2023

Wingo Thomas S, Gerasimov Ekaterina S, Canon Se Min, Lah James J, Levey Allan I, Wingo Aliza P

Abstract excerpt

INTRODUCTION: Despite an established link between depression and higher Alzheimer's disease (AD) risk, it is unclear whether the conditions share pathophysiology. Here, we investigated whether depression manifesting after age 50 is associated with a genetic predisposition to AD. METHODS: From the population-based Health and Retirement Study cohort with biennial assessments of depressive symptoms and cognitive...

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Source

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Identifiers

PMID: 35727298
DOI: 10.1002/alz.12716
PMCID: PMC9768095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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