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Article

Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.

Biological psychiatry - 1 Jul 2022

Harerimana Nadia V, Liu Yue, Gerasimov Ekaterina S, Duong Duc, Beach Thomas G, Reiman Eric M, Schneider Julie A, Boyle Patricia, Lori Adriana, Bennett David A, Lah James J, Levey Allan I, Seyfried Nicholas T, Wingo Thomas S, Wingo Aliza P

Abstract excerpt

BACKGROUND: Depression has been associated with a higher risk of Alzheimer's disease (AD) in several prospective studies; however, mechanisms underlying this association remain unclear. METHODS: We examined genetic correlation between depression and AD using linkage disequilibrium score regression. We then tested for evidence of causality between depression and AD using Mendelian randomization and genome-wide...

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Identifiers

PMID: 35177243
DOI: 10.1016/j.biopsych.2021.11.025
PMCID: PMC9200901

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