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Article

Age of onset and family history as indicators of polygenic risk for major depression.

Depression and anxiety - 1 May 2017

Docherty Anna R, Edwards Alexis C, Yang Fuzhong, Peterson Roseann E, Sawyers Chelsea, Adkins Daniel E, Moore Ashlee A, Webb Bradley T, Bacanu Silviu A, Flint Jonathan, Kendler Kenneth S

Abstract excerpt

BACKGROUND: The extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies. METHODS: This...

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PMID: 28152564
DOI: 10.1002/da.22607
PMCID: PMC5501985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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