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Article

Genetic evidence for a causal role of depression in late-onset Alzheimer disease: A Mendelian randomization study.

Medicine - 7 Aug 2026

Chen Yanlin, Chen Xiaohua

Abstract excerpt

Observational studies link psychiatric disorders to Alzheimer disease (AD), but whether these associations are causal remains unclear due to confounding and reverse causality. We aimed to dissect these relationships using genetic evidence. We performed a two-sample Mendelian randomization (MR) study to assess the causal effects of 7 psychiatric and neurodevelopmental disorders on AD and its subtypes. The primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42566636
DOI: 10.1097/MD.0000000000050116
PMCID: PMC13456805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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