Article
Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data.
Translational psychiatry - 18 Apr 2017
Gibson J, Russ T C, Adams M J, Clarke T-K, Howard D M, Hall L S, Fernandez-Pujals A M, Wigmore E M, Hayward C, Davies G, Murray A D, Smith B H, Porteous D J, Deary I J, McIntosh A M
Abstract excerpt
Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this relationship is uncertain. Both illnesses are polygenic, and shared genetic risk factors could explain some of the observed association. We used...
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