IKKα kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

Abstract excerpt

<h4>SUMMARY</h4> Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification of downstream effectors other than NF-κB has remained elusive. Analysis of IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKα is required for chromatin-binding dynamics upon damage. Moreover, IKKα induces the NF-κB-depe...

Topics

Open a Topic to create a Post that cites this publication.

• CAR-T cell therapy research
• Immune Cell Function and Interaction
• Kruppel-like factors research
• Multiple Myeloma Research and Treatments
• NF-κB Signaling Pathways
• PARP inhibition in cancer therapy
• Prostate Cancer Treatment and Research
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

a27f0742-1293-5cde-bb1c-b7826b5dc6a9

DOI

10.1101/2023.06.13.544711