Article

IL-6 Production Through Repression of UBASH3A Gene via Epigenetic Dysregulation of Super-Enhancer in CD4+T Cells in Rheumatoid Arthritis

2022-02-24

Abstract excerpt

<h4>Background: </h4> UBASH3A as a negative regulator of T-cell receptors (TCRs) signaling is a susceptible factor for rheumatoid arthritis (RA) patients who exhibit immune dysfunction. We studied UBASH3A expression in CD4 + T cells from healthy donors and RA patients, the involvement of super-enhancer (SE) in the control of UBASH3A expression, and the contribution of UBASH3A to proinflammatory cytokine production...

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Literature Corpus work: 2626374a-816e-58e9-a990-25cc38aed687
DOI: 10.21203/rs.3.rs-1373705/v1

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