Article
Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015
Yoshida Hideyuki, Bansal Kushagra, Schaefer Uwe, Chapman Trevor, Rioja Inmaculada, Proekt Irina, Anderson Mark S, Prinjha Rab K, Tarakhovsky Alexander, Benoist Christophe, Mathis Diane
Abstract excerpt
Aire controls immunologic tolerance by inducing a battery of thymic transcripts encoding proteins characteristic of peripheral tissues. Its unusually broad effect is achieved by releasing RNA polymerase II paused just downstream of transcriptional start sites. We explored Aire's collaboration with the bromodomain-containing protein, Brd4, uncovering an astonishing correspondence between those genes induced by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.