IKKα kinase coordinates BRD4 and STAT3 signaling to subvert DNA damage-based anticancer therapy

Abstract excerpt

<title>Abstract</title> <p>Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification of downstream effectors other than NF-kB has remained elusive. Analysis of IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKa is required for chromatin-binding dynamics upon damage. Moreover, IKKa induces the...

Topics

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• CAR-T cell therapy research
• DNA Repair Mechanisms
• Immune Cell Function and Interaction
• Kruppel-like factors research
• NF-κB Signaling Pathways
• PARP inhibition in cancer therapy
• PI3K/AKT/mTOR signaling in cancer
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

d00ee0ac-a23c-5653-bb15-986bd77abdac

DOI

10.21203/rs.3.rs-1922801/v2