Article

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development

2020-03-15

Abstract excerpt

Pathogenic IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange. The origin and development of these unique autoantibodies are not well understood. We examined MG patient-derived monoclonal autoantibodies (mAbs), their corresponding germline-encoded unmutated common ancestors (UCA) and monovalent antigen-binding fragments (Fabs) to investigate how ant...

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Literature Corpus work: cd1212f6-0d14-5dba-a2be-c16f66696d33
DOI: 10.1101/2020.03.14.988758

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