Article

MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity

2026-03-19

Abstract excerpt

Muscle-specific kinase (MuSK) is a pivotal player in forming and maintaining healthy neuromuscular junctions (NMJ). In MuSK myasthenia gravis (MG), autoantibodies targeting MuSK disrupt its function, impairing neuromuscular transmission and causing fatigable skeletal muscle weakness. MuSK autoantibodies predominantly belong to the IgG4 subclass, which bind in a monovalent fashion due to Fab-arm exchange, although...

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Literature Corpus work: 8b957fbc-7284-5966-a217-e2e6855f8772
DOI: 10.64898/2026.03.17.709302

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