Article

Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy

2022-07-24

Abstract excerpt

Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. In a subset of patients with MG, muscle-specific tyrosine kinase (MuSK) autoantibodies are present. MuSK MG patients respond well to CD20-mediated B cell depletion therapy (BCDT); most achieve complete stable remission. However, relapse often occurs. To further understand the immunomechanisms underlying relapse, w...

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Literature Corpus work: 6dd9f6d1-38e1-5e53-bd74-689ed3ca5b11
DOI: 10.1101/2022.07.21.22277677

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