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Article

B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis

26 Feb 2024

Abstract excerpt

Abstract B-cell maturation antigen (BCMA), expressed in plasmablasts and plasma cells, could serve as a promising therapeutic target for autoimmune diseases. We reported here chimeric antigen receptor (CAR) T cells targeting BCMA in two patients with highly relapsed and refractory myasthenia gravis (one with AChR-IgG, and one with MuSk-IgG). Both patients exhibited favorable safety profiles and persistent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38409527
DOI: 10.1038/s44321-024-00043-z

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