Article

Myasthenia thymus reprograms class-switched B cells into BAFF-dependent survivors

2025-09-21

Abstract excerpt

Myasthenia gravis (MG) presents a clinical challenge where autoantibody titers against the neuromuscular junction fail to predict disease severity or treatment response, and thymectomy provides inconsistent benefit despite removing the source of autoreactive B cells. We hypothesized that thymic B cells acquire survival mechanisms that bypass normal tolerance checkpoints, enabling persistence independent of antigen...

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Identifiers and source

Literature Corpus work: 8c0be148-07a1-571f-b696-859a7b182702
DOI: 10.1101/2025.09.19.677075

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