Article

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis

2020-09-24

Abstract excerpt

Human IgG4 usually displays anti-inflammatory activity, and observations of IgG4 autoantibodies causing severe autoimmune disorders are therefore poorly understood. In blood, IgG4 antibodies naturally engage in a stochastic process termed Fab-arm exchange in which unrelated IgG4s exchange half-molecules continuously. The resulting IgG4 antibodies are composed of two different binding sites, thereby acquiring monov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5bd2187b-7eea-534a-966a-f635f15ef154
DOI: 10.1101/2020.09.24.296293

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravisDOI 10.1101/2020.09.24.296293Read

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravisSemantic proximity Read

Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody developmentSemantic proximity Read

MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificitySemantic proximity Read

Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis.Semantic proximity Read

Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapySemantic proximity Read

Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapySemantic proximity Read

Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer modelsSemantic proximity Read

Distribution and Temporal Changes of Autoantibody-Mediated Pathogenic Mechanisms Among Acetylcholine Receptor-Positive Myasthenia Gravis PatientsSemantic proximity Read

Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?Semantic proximity Read

Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.Semantic proximity Read

Distinct transcriptional programs define human IgG4 <sup>+</sup> memory B cellsSemantic proximity Read

Phenotype, Severity, and Therapy of Patients With LRP4 Antibody-Associated Myasthenia Gravis in the German Myasthenia Gravis Registry.Semantic proximity Read