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Article

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis

22 Mar 2021

Abstract excerpt

Human immunoglobulin (Ig) G4 usually displays antiinflammatory activity, and observations of IgG4 autoantibodies causing severe autoimmune disorders are therefore poorly understood. In blood, IgG4 naturally engages in a stochastic process termed "Fab-arm exchange" in which unrelated IgG4s exchange half-molecules continuously. The resulting IgG4 antibodies are composed of two different binding sites, thereby...

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PMID: 33753489
DOI: 10.1073/pnas.2020635118

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