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Article

Contribution of NLRP3-GSDMD axis to PDGF-BB-induced vascular smooth muscle cell phenotypic transition.

American journal of physiology. Cell physiology - 1 Aug 2025

Wang Yun-Ting, Moura Alexandra K, Zuo Rui, Guan Yinglu, Lee Emily A, Hu Jenny Z, Roudbari Kiana, Wang Zhengchao, Wang Mi, Li Pin-Lan, Hao Jiukuan, Li Xiang, Zhang Yang

Abstract excerpt

Intimal hyperplasia, a pathological form of vascular remodeling, is a hallmark of several cardiovascular diseases, including restenosis following angioplasty. Vascular smooth muscle cell (VSMC) phenotypic transition plays a critical role in the development of vascular intimal hyperplasia. This study investigates the role of the NOD-like receptor pyrin domain 3 (NLRP3) inflammasome and its downstream effector,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 40691040
DOI: 10.1152/ajpcell.00226.2025
PMCID: PMC12369509

Genes

GSDMD
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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