Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis.

International journal of molecular sciences - 29 Dec 2021

Burger Fabienne, Baptista Daniela, Roth Aline, da Silva Rafaela Fernandes, Montecucco Fabrizio, Mach François, Brandt Karim J, Miteva Kapka

Abstract excerpt

(1) Background: Monocytes and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome orchestrate lipid-driven amplification of vascular inflammation promoting the disruption of the fibrous cap. The components of the NLRP3 inflammasome are expressed in macrophages and foam cells within human carotid atherosclerotic plaques and VSMCs in hypertension. Whether monocytes and NLRP3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carotid Artery Diseases
Share to Cell Transdifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypercholesterolemia

Share to Inflammasomes

Share to Interleukin-1beta

Share to Lipoproteins, LDL

Share to Myocytes, Smooth Muscle

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 35008765
DOI: 10.3390/ijms23010340
PMCID: PMC8745068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis.PMID 35008765Read ↗

Vascular Smooth Muscle–Specific NLRP3 Hyperactivation Drives Arterial Intimal Hyperplasia in MiceSemantic proximity Read ↗

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.Semantic proximity Read ↗

Contribution of NLRP3-GSDMD axis to PDGF-BB-induced vascular smooth muscle cell phenotypic transition.Semantic proximity Read ↗

Artesunate inhibits macrophage-like phenotype switching of vascular smooth muscle cells and attenuates vascular inflammatory injury in atherosclerosis via NLRP3.Semantic proximity Read ↗

Deciphering Macrophage Phenotypes upon Lipid Uptake and AtherosclerosisSemantic proximity Read ↗

Interplay Between KLF4, STAT, IRF and NF-κB in VSMC and Macrophage Plasticity During Vascular Inflammation and AtherosclerosisSemantic proximity Read ↗

Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic TargetsSemantic proximity Read ↗

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis.Semantic proximity Read ↗

Chronic inflammation and vascular cell plasticity in atherosclerosis.Semantic proximity Read ↗

Regulation of Macrophage Activation and Differentiation in AtherosclerosisSemantic proximity Read ↗

Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage Pathogenesis.Semantic proximity Read ↗

Macrophage Diversity and Polarization in AtherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.