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Recent insights into the cellular biology of atherosclerosis

13 Apr 2015

Abstract excerpt

Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein retention. Over time, this process stimulates a nonresolving inflammatory response that can cause intimal destruction, arterial thrombosis, and end-organ ischemia. Recent advances highlight important...

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PMID: 25869663
DOI: 10.1083/jcb.201412052

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