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Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis

1 Jan 2020

Abstract excerpt

In the progression of atherosclerosis, macrophages are the key immune cells for foam cell formation. During hyperlipidemic condition, phagocytic cells such as monocytes and macrophages uptake oxidized low-density lipoproteins (oxLDLs) accumulated in subintimal space, and lipid droplets are accumulated in their cytosols. In this review, we discussed the characteristics and phenotypic changes of macrophages in...

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PMID: 32655970
DOI: 10.4110/in.2020.20.e22

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