Article

HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc-Driven Small Cell Lung Cancer

2025-08-09

Abstract excerpt

<h4>SUMMARY</h4> Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy, accounting for approximately 15% of all lung cancer cases. Characterized by low immunogenicity, SCLC may utilize epigenetic mechanisms to evade immune detection. Here, we demonstrate that entinostat, a class I histone deacetylase inhibitor (HDACi) upregulates immune-related genes in human SCLC cells. In vivo, we confirmed entinostat...

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Literature Corpus work: cce6b2d8-b534-516f-928e-8990b930b178
DOI: 10.1101/2025.08.06.668958

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