Article

Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

2026-04-08

Abstract excerpt

<h4>SUMMARY</h4> Although small cell lung cancer (SCLC) comprises transcription factor (TF)-defined molecular subtypes (ASCL1, NEUROD1, POU2F3), the extent to which these subtypes predict response to clinically effective therapy in patients—and whether therapy can select for subtype switching—remains unknown. The recent approval of the DLL3×CD3 bispecific T-cell engager tarlatamab represents one of the first mean...

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Literature Corpus work: b7734f96-fe6b-5934-aff0-06c04d5155cc
DOI: 10.64898/2026.04.02.715020

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