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Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

15 Oct 2021

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 SCLC transcriptomes. We observe greater tumor diversity in...

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PMID: 34653364
DOI: 10.1016/j.ccell.2021.09.008

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