Article

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

2020-07-14

Abstract excerpt

<h4>SUMMARY</h4> How anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. We characterized immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluorescence. Our results demonstrated that anti-tumor immunity evolved as a continuum from lung preneoplasia, to preinvasive ADC, minimally-i...

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Literature Corpus work: 6d7d555e-6d5d-5840-8c76-001a43cb1e2f
DOI: 10.1101/2020.07.11.20142992

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