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Targeting the epigenetic processes to enhance antitumor immunity in small cell lung cancer

18 Feb 2022

Abstract excerpt

Dysregulation of the epigenetic processes, such as DNA methylation, histone modifications, and modulation of chromatin states, drives aberrant transcription that promotes initiation and progression of small cell lung cancer (SCLC). Accumulating evidence has proven crucial roles of epigenetic machinery in modulating immune cell functions and antitumor immune response. Epigenetics-targeting drugs such as DNA...

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PMID: 35189321
DOI: 10.1016/j.semcancer.2022.02.018

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