Article

HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling

2023-10-10

Abstract excerpt

Single-cell DNA-sequencing (scDNA-seq) enables decoding somatic cancer variation. Existing methods are hampered by low throughput or cannot be combined with transcriptome sequencing in the same cell. We propose HIPSD&R-seq ( HI gh-through P ut S ingle-cell D na and R na-seq), a scalable yet simple assay to profile low-coverage DNA and RNA in thousands of cells in parallel. Our approach builds on an accessible...

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Literature Corpus work: 00a3cd9e-fde7-50bc-ab1c-23ff9599a26e
DOI: 10.1101/2023.10.09.561487

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