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Precision Oncology Through Dialogue: AI-HOPE-RTK-RAS Integrates Clinical and Genomic Insights into RTK-RAS Alterations in Colorectal Cancer

2025-06-07

Abstract excerpt

<h4>Introduction</h4> The RTK-RAS signaling cascade is a central axis in colorectal cancer (CRC) pathogenesis, governing cellular proliferation, survival, and therapeutic resistance. Somatic alterations in key pathway genes—including KRAS, NRAS, BRAF, and EGFR—are pivotal to clinical decision-making in precision oncology. However, the integration of these genomic events with clinical and demographic data remains h...

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Literature Corpus work
b50ac222-ed5f-5c45-ae68-082585b9958d
DOI
10.1101/2025.06.06.25329155
Open publication

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