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Ribosomal DNA copy number loss and sequence variation in cancer.

PLoS genetics - 1 Jun 2017

Xu Baoshan, Li Hua, Perry John M, Singh Vijay Pratap, Unruh Jay, Yu Zulin, Zakari Musinu, McDowell William, Li Linheng, Gerton Jennifer L

Abstract excerpt

Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs its copy number, stability, and sequence in the mammalian genome due to challenges associated with mapping and analysis. We applied computational and droplet digital PCR approaches to measure rDNA copy number in normal...

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PMID: 28640831
DOI: 10.1371/journal.pgen.1006771
PMCID: PMC5480814

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PTEN

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